Retatrutide
High-purity research peptide
$150.00$68.00
Out of stock
As an investigational molecule Retatrutide is emerging as a promising therapeutic agent in the field of obesity management. Revealed in phase 2 trials, retatrutide has demonstrated significant efficacy in weight reduction among participants with obesity or overweight, achieving a mean weight loss of up to 17.5% over 24 weeks and 24.2% over 48 weeks. These results were highlighted at the American Diabetes Association's 83rd Scientific Sessions and published in The New England Journal of Medicine.
Distinctive in its mechanism, Retatrutide combines glucagon receptor agonism with GIP and GLP-1 receptor agonism. This novel approach may account for the notable weight reduction observed in trials, surpassing many current treatments. The TRIUMPH phase 3 development program is further exploring Retatrutide's efficacy in chronic weight management and associated conditions like obstructive sleep apnea (OSA) and knee osteoarthritis (OA) in individuals with obesity and overweight.
In comparison to Semaglutide and Tirzepatide, Retatrutide's unique inclusion of glucagon receptor agonism alongside GIP and GLP-1 receptor agonism offers a distinct pharmacological profile. While Semaglutide is a GLP-1 receptor agonist and Tirzepatide combines GLP-1 and GIP receptor agonism, retatrutide's triple mechanism could potentially provide broader metabolic benefits. The phase 2 study, involving various doses and dose-escalation regimens, underscores retatrutide's safety profile, similar to other incretin-based therapies, with gastrointestinal side effects being the most common adverse events.
The ongoing research and trials will determine retatrutide's place in treating obesity and its complications, potentially broadening the spectrum of effective pharmacotherapeutic options for this chronic disease.
Premium Retatrutide—specifically formulated for advanced research applications. Each 3ml glass vial contains a precise quantity of high-purity lyophilized Retatrutide, produced in a GMP lab and securely sealed to maintain integrity and safety during handling and storage.
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